CCG 2979 ( CCG2979 )

Catalog No. M14070 CAS No. 328070-87-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CCG 2979
Note

Research use only, not for human use.
Brief Description

CCG 2979 is a small molecule inhibitor of gene expression of streptokinase (SK), a critical group A streptococcal (GAS) virulence factor.
Description

CCG 2979 is a small molecule inhibitor of gene expression of streptokinase (SK), a critical group A streptococcal (GAS) virulence factor; inhibits expression of SK by 60% at 50 uM based on activity assay, also inhibits the production of active SK protein; enhances granulocyte phagocytosis and killing of GAS in an in vitro assay, also protecteds mice from GAS-induced mortality in vivo.
Synonyms

CCG2979
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

CAS Number

328070-87-7
Formula Weight

394.58
Molecular Formula

C24H30N2OS
Purity

>98% (HPLC)
Solubility

——
SMILES

CCCCSC1=NC2=C(C(=O)N1CC=C)C3(CCCCC3)CC4=CC=CC=C42
Chemical Name

2-butylsulfanyl-3-prop-2-enylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one

1. Sun H, et al. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3469-74.

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